Isolation of bilobalide and ginkgolide a from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics.
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چکیده
منابع مشابه
Efficient extraction of ginkgolides and bilobalide from Ginkgo biloba leaves.
An efficient and rapid protocol has been developed for extracting ginkgolides and bilobalide (terpene trilactones) from Ginkgo biloba leaves. The procedure takes advantage of the extraordinary stability of the terpene trilactone structure to a variety of chemical treatments, especially oxidation, despite the presence of multiple oxygen functions. The protocol involves boiling the aqueous extrac...
متن کاملQuantitative Analysis of Bilobalide and Ginkgolides from Ginkgo biloba Leaves and Ginkgo Products Using H-NMR
than 2000 years, making it one of the oldest known medicinal plants. It is of great interest because its leaves possess pharmacological properties that include radical scavenging, improved blood flow, vasoprotection, and anti-PAF (platelet aggregating factor) activity. In numerous experimental models, a ginkgo extract was found to affect vascular and metabolic disturbances as well as neurologic...
متن کاملDistinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.
In the present study, primary cultures of rat hepatocytes were treated for 48 h with one of several extracts of Ginkgo biloba (10, 100, or 1000 microg/ml). Maximal increase in CYP2B1 and CYP3A23 mRNA levels was obtained at 100 microg/ml. This concentration of G. biloba extract also increased CYP3A2 and CYP3A18 mRNA expression in addition to CYP2B-mediated 7-benzyloxyresorufin O-dealkylation (BR...
متن کاملGinkgo biloba leaf extract (EGb 761) enhances catalepsy induced by haloperidol and L-nitroarginine in mice.
Ginkgo biloba extract EGb 761 has been reported to have therapeutic effects which have been attributed to anti-oxidant and free radical-scavenging activities, including a direct action on nitric oxide production. L G-nitro-arginine (L-NOARG), a nitric oxide synthase inhibitor, and haloperidol, a drug that blocks dopamine receptors, are both known to induce catalepsy in rodents. Nitric oxide has...
متن کاملA study of the effect of Ginkgo biloba extract on MK801 induced forgetfulness in rats
Introduction: Many people with amnesia would like to try herbal therapies. Ginkgo biloba is one of the most popular herbs which is used to treat amnesia. The beneficial effects of this plant, however, has not been scientifically assessed yet. Although, there have been some reports on the memory enhancement effect of Ginkgo biloba, the mechanism of its action is not yet explained well. Consi...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1993
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.16.210